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Target
Gamma-secretase-activating protein
Ligand
BDBM157135
Substrate
n/a
Meas. Tech.
HTRF Biochemical Assay
IC50
1.0±0.0 nM
Citation
 Shelton, CC; Tian, Y; Li, Y γ-Secretase substrates and methods of use US Patent  US9023767 Publication Date 5/5/2015 
Target
Name:
Gamma-secretase-activating protein
Synonyms:
GSAP | GSAP_HUMAN | Gamma-secretase | PION
Type:
Protein
Mol. Mass.:
97808.44
Organism:
Homo sapiens (Human)
Description:
A4D1B5
Residue:
854
Sequence:
MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYTYKDDKGNVVFGLYDCQTRQNELLYTFEKDLQVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSKCLTLLVEIHPVNNVKVLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQFRIHVAQEDGNRVVIKNSGHLPRDRIAEDFVWAQWDMSEQRLYYIDLKKSRSILKCIQFYADESYNLMFEVPLDISLSNSGFKLVNFGCDYHQYRDKFSKHLTLCVFTNHTGSLCVCYSPKCASWGQITYSVFYIHKGHSKTFTTSLENVGSHMTKGITFLNLDYYVAVYLPGHFFHLLNVQHPDLICHNLFLTGNNEMIDMLPHCPLQSLSGSLVLDCCSGKLYRALLSQSSLLQLLQNTCLDCEKMAALHCALYCGQGAQFLEAQIIQWISENVSACHSFDLIQEFIIASSYWSVYSETSNMDKLLPHSSVLTWNTEIPGITLVTEDIALPLMKVLSFKGYWEKLNSNLEYVKYAKPHFHYNNSVVRREWHNLISEEKTGKRRSAAYVRNILDNAVKVISNLEARNLGPRLTPLLQEEDSHQRLLMGLMVSELKDHFLRHLQGVEKKKIEQMVLDYISKLLDLICHIVETNWRKHNLHSWVLHFNSRGSAAEFAVFHIMTRILEATNSLFLPLPPGFHTLHTILGVQCLPLHNLLHCIDSGVLLLTETAVIRLMKDLDNTEKNEKLKFSIIVRLPPLIGQKICRLWDHPMSSNIISRNHVTRLLQNYKKQPRNSMINKSSFSVEFLPLNYFIEILTDIESSNQALYPFEGHDNVDAEFVEEAALKHTAMLLGL
  
Inhibitor
Name:
BDBM157135
Synonyms:
US9023767, GSI-34
Type:
Small organic molecule
Emp. Form.:
C25H24ClFN2O4S2
Mol. Mass.:
535.05
SMILES:
Fc1ccc(OCC(=O)Nc2ccc3CC4CCC(Cc3c2)C4NS(=O)(=O)c2ccc(Cl)s2)cc1
Structure:
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