Reaction Details Report a problem with these data
Target
Lipopolysaccharide-induced tumor necrosis factor-alpha factor
Ligand
BDBM235382
Substrate
n/a
Meas. Tech.
TNF inhibition assay
IC50
31.0±n/a nM
Citation
Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors US Patent US10085990 Publication Date 10/2/2018
More Info.:
Target
Name:
Lipopolysaccharide-induced tumor necrosis factor-alpha factor
Synonyms:
LITAF | LITAF_HUMAN | LPS-induced TNF-alpha factor | PIG7 | SIMPLE | Small integral membrane protein of lysosome/late endosome | TNF-alpha | p53-induced gene 7 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17106.57
Organism:
Human
Description:
TNF-alpha 0 HUMAN::Q99732
Residue:
161
Sequence:
MSVPGPYQAATGPSSAPSAPPSYEETVAVNSYYPTPPAPMPGPTTGLVTGPDGKGMNPPSYYTQPAPIPNNNPITVQTVYVQHPITFLDRPIQMCCPSCNKMIVSQLSYNAGALTWLSCGSLCLLGCIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL