Reaction Details
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Cell division protein FtsZ
Ligand
BDBM186046
Substrate
n/a
Meas. Tech.
GTPase Activity Assay
pH
6.5±n/a
Temperature
298.15±n/a K
IC50
160000±30000 nM
Comments
extracted
Citation
Bewley, CA; Wipf, P Chrysophaentin analogs that inhibit FtsZ protein US Patent US9169182 Publication Date 10/27/2015 More Info.:
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_ECOLI | ftsZ | sfiB | sulB
Type:
Protein
Mol. Mass.:
40305.83
Organism:
Escherichia coli
Description:
P0A9A6
Residue:
383
Sequence:
MFEPMELTNDAVIKVIGVGGGGGNAVEHMVRERIEGVEFFAVNTDAQALRKTAVGQTIQIGSGITKGLGAGANPEVGRNAADEDRDALRAALEGADMVFIAAGMGGGTGTGAAPVVAEVAKDLGILTVAVVTKPFNFEGKKRMAFAEQGITELSKHVDSLITIPNDKLLKVLGRGISLLDAFGAANDVLKGAVQGIAELITRPGLMNVDFADVRTVMSEMGYAMMGSGVASGEDRAEEAAEMAISSPLLEDIDLSGARGVLVNITAGFDLRLDEFETVGNTIRAFASDNATVVIGTSLDPDMNDELRVTVVATGIGMDKRPEITLVTNKQVQQPVMDRYQQHGMAPLTQEQKPVAKVVNDNAPQTAKEPDYLDIPAFLRKQAD
Inhibitor
Name:
BDBM186046
Synonyms:
US9169182, J24
Type:
Small organic molecule
Emp. Form.:
C16H14Cl2O4
Mol. Mass.:
341.186
SMILES:
Oc1cc(O)cc(C\C(Cl)=C/Cc2cc(O)c(Cl)cc2O)c1
Structure:
