Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM206093
Substrate
IRAK-4 Peptide Substrate
Meas. Tech.
In vitro IRAK-1 and IRAK-4 Assay
IC50
5±n/a nM
Citation
Arora, N; Chen, S; Hermann, JC; Kuglstatter, A; Labadie, SS; Lin, CJ; Lucas, MC; Moore, AG; Papp, E; Talamas, FX; Wanner, J; Zhai, Y Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators US Patent US9255110 Publication Date 2/9/2016
More Info.:
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Human
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Inhibitor
Name:
BDBM206093
Synonyms:
US9255110, 5
Type:
Small organic molecule
Emp. Form.:
C20H22ClN5O2
Mol. Mass.:
399.874
SMILES:
CC(O)C1CCN(CC1)c1ccc(Cl)cc1NC(=O)c1cnn2cccnc12
Substrate
Name:
IRAK-4 Peptide Substrate
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
2290.62
Organism:
Human
Description:
IRAK-1 (360-380); IRAK-4 Peptide Substrate
Residue:
21
Sequence:
KKARFSRFAGSSPSQSSMVAR