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Target
Fibroblast growth factor receptor 4 [388-802]
Ligand
BDBM209307
Substrate
n/a
Meas. Tech.
Biochemical Kinase Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
0.8±n/a nM
Comments
extracted
Citation
 Buschmann, N; Fairhurst, RA; Furet, P; Knöpfel, T; Leblanc, C; Liao, L; Mah, R; Nimsgern, P; Ripoche, S; Xiong, J; Han, B; Wang, C; Zhao, X Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors US Patent  US9266883 Publication Date 2/23/2016 
Target
Name:
Fibroblast growth factor receptor 4 [388-802]
Synonyms:
FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor 4 (FGFR4) | JTK2 | TKF
Type:
Protein
Mol. Mass.:
45529.19
Organism:
Homo sapiens (Human)
Description:
GST-FGFR4(388-802)
Residue:
415
Sequence:
GLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM209307
Synonyms:
US9266883, 65
Type:
Small organic molecule
Emp. Form.:
C25H28N6O4
Mol. Mass.:
476.5276
SMILES:
OC[C@H]1[C@@H]2CC[C@@H](C2)[C@H]1Nc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc23)ncc1C#N |r|
Structure:
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