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Target
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]
Ligand
BDBM211967
Substrate
n/a
Meas. Tech.
MKNK1 Kinase High ATP Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
389±n/a nM
Comments
extracted
Citation
 Eis, K; Puehler, F; Zorn, L; Schulze, V; Sülzle, D; Lienau, P; Hägebarth, A; Petersen, K; Bömer, U Amino-substituted imidazopyridazines US Patent  US9290482 Publication Date 3/22/2016 
Target
Name:
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]
Synonyms:
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase signal-integrating kinase 1 (MNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)(T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase-interacting serine/threonine-protein kinase 1 (T344D) | MKNK1 | MKNK1 (aa 1-424) T344D | MKNK1_HUMAN | MNK1 | MNK1a
Type:
Protein
Mol. Mass.:
47416.00
Organism:
Homo sapiens (Human)
Description:
Q9BUB5-2 with T344D
Residue:
424
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPDPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM211967
Synonyms:
US9290482, 7
Type:
Small organic molecule
Emp. Form.:
C25H22FN5O3
Mol. Mass.:
459.4723
SMILES:
COc1nccc2oc(cc12)-c1cnc2ccc(O[C@@H](CNC3CC3)c3ccc(F)cc3)nn12 |r|
Structure:
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