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Target
Isoform Tau-F of Microtubule-associated protein tau
Ligand
BDBM75309
Substrate
n/a
Meas. Tech.
Tau Protein Assay
pH
7.4±n/a
IC50
9.6e+2± 2.5e+2 nM
Comments
extracted
Citation
 Schafer, KN; Cisek, K; Huseby, CJ; Chang, E; Kuret, J Structural determinants of Tau aggregation inhibitor potency. J Biol Chem 288:32599-611 (2013) [PubMed]  Article 
Target
Name:
Isoform Tau-F of Microtubule-associated protein tau
Synonyms:
MAPT | MAPTL | MTBT1 | Microtubule-associated protein | Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R) | Microtubule-associated protein tau (TAU)(2N4R) | TAU | TAU_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45857.42
Organism:
Homo sapiens (Human)
Description:
P10636-8
Residue:
441
Sequence:
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
  
Inhibitor
Name:
BDBM75309
Synonyms:
(2Z)-3-ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzothiazole;iodide | Cyanines, 7 | MLS001032120 | SMR000718614 | cid_5709759
Type:
Small organic molecule
Emp. Form.:
C21H21N2S2
Mol. Mass.:
365.534
SMILES:
CCN1\C(Sc2ccccc12)=C\C=C\c1sc2ccccc2[n+]1CC
Structure:
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