Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM221916
Substrate
n/a
Meas. Tech.
β-Arrestin Assay
Temperature
298.15±n/a K
EC50
27±n/a nM
Comments
extracted
Citation
 Zhang, X; Wang, E; Guo, J; Niu, S; Dai, Z; Zheng, N; Ji, L; Wang, Z; Liang, T Heterocyclic group contained amino-methanol derivative, and salt, synthetic method and use thereof US Patent  US9315492 Publication Date 4/19/2016 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
Edg1 | Lpb1 | S1PR1_MOUSE | S1pr1 | Sphingosine 1-phosphate receptor 1 | Sphingosine 1-phosphate receptor 1 (S1P1)
Type:
Enzyme
Mol. Mass.:
42663.66
Organism:
Mus musculus (Mouse)
Description:
O08530
Residue:
382
Sequence:
MVSTSIPEVKALRSSVSDYGNYDIIVRHYNYTGKLNIGAEKDHGIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIVSCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSSHPQKDDGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM221916
Synonyms:
US9315492, 15
Type:
Small organic molecule
Emp. Form.:
C21H23N3O3
Mol. Mass.:
365.4256
SMILES:
COc1ccc(cc1C)-c1nnc(o1)-c1ccc2CCC(N)(CO)Cc2c1
Structure:
Search PDB for entries with ligand similarity: