Reaction Details Report a problem with these data
Target
Beta-galactosidase [24-677,R201C]
Ligand
BDBM228803
Substrate
4-Methylumbelliferyl-β-D-galactopyranoside
Meas. Tech.
β-Gal Inhibitory Assay
pH
4.5±n/a
Temperature
310.15±n/a K
Ki
3.204e+5±n/a nM
Citation
 Suzuki, H; Ohto, U; Higaki, K; Mena-Barragán, T; Aguilar-Moncayo, M; Ortiz Mellet, C; Nanba, E; Garcia Fernandez, JM; Suzuki, Y; Shimizu, T Structural basis of pharmacological chaperoning for human ß-galactosidase. J Biol Chem 289:14560-8 (2014) [PubMed]  Article 
Target
Name:
Beta-galactosidase [24-677,R201C]
Synonyms:
BGAL_HUMAN | ELNR1 | GLB1 | beta-Galactosidase (β-Gal)(R201C)
Type:
Enzyme
Mol. Mass.:
73534.19
Organism:
Homo sapiens (Human)
Description:
Human β-Gal (24-677 aa) with R201C mutation
Residue:
654
Sequence:
LRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLCFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV
  
Inhibitor
Name:
BDBM228803
Synonyms:
5N,6S-(N'-butyliminomethylidene)-6-thiogalactonojirimycin | 6S-NBI-GJ
Type:
Small organic molecule
Emp. Form.:
C11H20N2O4S
Mol. Mass.:
276.352
SMILES:
CCCC\N=C1\SCC2[C@H](O)[C@H](O)C(O)[C@@H](O)N12 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM50361738
Synonyms:
CHEMBL1393422
Type:
Small organic molecule
Emp. Form.:
C16H18O8
Mol. Mass.:
338.3093
SMILES:
Cc1cc(=O)oc2cc(O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)ccc12
Structure:
Search PDB for entries with ligand similarity: