Target

Ligand

Substrate

Meas. Tech.

Kinase Inhibition Assay

Citation

 Kuo, GH; Prouty, C; Wang, A; Emanuel, S; Deangelis, A; Zhang, Y; Song, F; Beall, L; Connolly, PJ; Karnachi, P; Chen, X; Gruninger, RH; Sechler, J; Fuentes-Pesquera, A; Middleton, SA; Jolliffe, L; Murray, WV Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors. J Med Chem 48:4892-909 (2005) [PubMed]  Article Copy BDB DOI

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Name:

Glycogen synthase kinase-3 beta [7-25]

Synonyms:

G1T8E2_RABIT | GSK-3, beta | GSK3B | Glycogen Synthase Kinase-3, beta

Type:

Enzyme fragment

Mol. Mass.:

1972.14

Organism:

Oryctolagus cuniculus (rabbit)

Description:

Glycogen Synthase Kinase-3 is the beta isoform of the rabbit enzyme produced in E.coli.. Only partial sequence is available.

Residue:

19

Sequence:

TTSFAESCKPVQQPSAFGS

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Blast E-value cutoff:

Name:

BDBM6416

Synonyms:

3-[(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridin-3-yl)amino]propan-1-ol | 3-[[5-[6-[(3-chlorophenyl)amino]pyrazinyl]-3-pyridinyl]amino]-1-propanol | Pyrazine-Pyridine Biheteroaryl 7 | Pyrazine-Pyridine deriv. 15

Type:

Small organic molecule

Emp. Form.:

C18H18ClN5O

Mol. Mass.:

355.821

SMILES:

OCCCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1

Structure:

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Similarity to this molecule at least:

Name:

GSK-3 Peptide Substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

3277.76

Organism:

n/a

Description:

n/a

Residue:

27

Sequence:

ITINKRREILSRRPPHSPHSYRAMIDE