Reaction Details Report a problem with these data
Target
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188]
Ligand
BDBM238901
Substrate
n/a
Meas. Tech.
Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay
Temperature
298.15±n/a K
IC50
1.8±n/a nM
Comments
extracted
Citation
Furet, P; Guagnano, V; Holzer, P; Kallen, J; Mah, R; Masuya, K; Schlapbach, A; Vaupel, A Substituted purinone compounds US Patent US9403827 Publication Date 8/2/2016
More Info.:
Target
Name:
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188]
Synonyms:
p53-MDM2
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cellular tumor antigen p53 [18-26]
Synonyms:
P53 | P53_HUMAN | TP53 | Tumor suppressor p53
Type:
Protein
Mol. Mass.:
1122.31
Organism:
Human
Description:
aa 18-26
Residue:
9
Sequence:
TFSDLWKLL
Component 2
Name:
E3 ubiquitin-protein ligase Mdm2 [2-188]
Synonyms:
E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN
Type:
Protein
Mol. Mass.:
21187.98
Organism:
Human
Description:
aa 2-188
Residue:
187
Sequence:
CNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDS