Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM239866
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
17±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239866
Synonyms:
US9403767, 19
Type:
Small organic molecule
Emp. Form.:
C25H35ClN2O2S
Mol. Mass.:
463.076
SMILES:
CCCCC1(CNS(=O)(=O)c2ccc(Cl)cc2)CCC(CC1)(N(C)C)c1ccccc1 |(-.89,-6.6,;.62,-6.33,;1.15,-4.89,;2.67,-4.62,;3.66,-5.8,;4.65,-4.62,;4.12,-3.17,;5.11,-1.99,;3.93,-1,;6.29,-2.98,;6.1,-.81,;5.57,.63,;6.56,1.81,;8.08,1.55,;9.07,2.73,;8.61,.1,;7.62,-1.08,;4.99,-6.57,;4.99,-8.11,;3.66,-8.88,;2.32,-8.11,;2.32,-6.57,;4.65,-10.06,;4.12,-11.51,;6.16,-9.79,;2.67,-10.06,;3.19,-11.51,;2.2,-12.69,;.69,-12.42,;.16,-10.97,;1.15,-9.79,)|
Structure:
Search PDB for entries with ligand similarity: