Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM239887
Substrate
n/a
Meas. Tech.
Binding Assay
Temperature
298.15±n/a K
Ki
1.24±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM239887
Synonyms:
US9403767, 45
Type:
Small organic molecule
Emp. Form.:
C24H31FN2O2S
Mol. Mass.:
430.579
SMILES:
CN(C)C1(CCC(C)(CNS(=O)(=O)\C=C\c2ccccc2)CC1)c1cccc(F)c1 |(14.7,-7.6,;15.38,-6.21,;16.68,-7.03,;14.51,-4.94,;14.46,-3.4,;13.1,-2.67,;11.8,-3.49,;10.93,-2.21,;10.26,-3.49,;9.49,-4.82,;7.95,-4.82,;7.95,-3.28,;6.41,-4.82,;7.95,-6.36,;6.61,-7.13,;6.61,-8.67,;7.95,-9.44,;7.95,-10.98,;6.61,-11.75,;5.28,-10.98,;5.28,-9.44,;11.85,-5.03,;13.21,-5.75,;16.05,-4.94,;16.82,-6.27,;18.36,-6.27,;19.13,-4.94,;18.36,-3.6,;19.13,-2.27,;16.82,-3.6,)|
Structure:
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