Reaction Details Report a problem with these data
Target
Genome polyprotein [2420-3010,S282T]
Ligand
BDBM240843
Substrate
n/a
Meas. Tech.
HCV Replicon Assay
pH
7.5±n/a
Temperature
300.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
 Du, J; Sofia, MJ 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections US Patent  US9394331 Publication Date 7/19/2016 
Target
Name:
Genome polyprotein [2420-3010,S282T]
Synonyms:
POLG_HCVCO | RNA-directed RNA polymerase (NS5B) (S282T)
Type:
Enzyme
Mol. Mass.:
65797.38
Organism:
HCV
Description:
S282T
Residue:
591
Sequence:
SMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRATGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTEAMTRYSAPPGDPPKPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
  
Inhibitor
Name:
BDBM240843
Synonyms:
US9394331, 137 | US9394331, 49
Type:
Small organic molecule
Emp. Form.:
C12H17N3O5
Mol. Mass.:
283.2805
SMILES:
Nc1ccn(C2OC(CO)[C@@H](O)[C@]22CCCO2)c(=O)n1 |r|
Structure:
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