Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [57-168]
Ligand
BDBM245888
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
pH
6±n/a
Temperature
298.15±n/a K
Ki
1040±n/a nM
Comments
extracted
Citation
 Bogdan, A; Kati, WM; McDaniel, KF; Park, CH; Sheppard, GS; Wang, L Bromodomain inhibitors US Patent  US9428514 Publication Date 8/30/2016 
Target
Name:
Bromodomain-containing protein 4 [57-168]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(aa 57-168) | Bromodomain-containing protein 4 (BRD4-BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13496.03
Organism:
Homo sapiens (Human)
Description:
BDI: amino acids K57-E168
Residue:
112
Sequence:
KRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM245888
Synonyms:
US9428514, 76
Type:
Small organic molecule
Emp. Form.:
C31H30F2N2O5S
Mol. Mass.:
580.642
SMILES:
CCOc1cc(=O)n(C)cc1-c1cc(ccc1Oc1ccc(F)cc1F)N(CC1CC1)S(=O)(=O)Cc1ccccc1
Structure:
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