Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM248987
Substrate
n/a
Meas. Tech.
In Vitro Cell Proliferation Potency Assay
IC50
212±n/a nM
Citation
 Do, S; Hu, H; Kolesnikov, A; Tsui, VH; Wang, X 5-azaindazole compounds and methods of use US Patent  US9434725 Publication Date 9/6/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM1_MOUSE | Pim-1 | Pim1
Type:
Enzyme
Mol. Mass.:
44550.25
Organism:
Mus musculus (Mouse)
Description:
P06803
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVADNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSDFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEDLARGFFWQVLEAVRHCHNCGVLHRDIKDENILIDLSRGEIKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQVFFRQTVSSECQHLIKWCLSLRPSDRPSFEEIRNHPWMQGDLLPQAASEIHLHSLSPGSSK
  
Inhibitor
Name:
BDBM248987
Synonyms:
US9434725, 218
Type:
Small organic molecule
Emp. Form.:
C22H24N8O
Mol. Mass.:
416.479
SMILES:
Cc1cncc(n1)-c1cc2n(ncc2cn1)-c1ccc(CO)c(n1)N1CCC[C@H](N)C1 |r|
Structure:
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