Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
Ligand
BDBM6639
Substrate
G1 peptide
Meas. Tech.
CDKs Assay
pH
7.4±n/a
Temperature
303.15±n/a K
IC50
350000±n/a nM
Citation
Honma, T; Hayashi, K; Aoyama, T; Hashimoto, N; Machida, T; Fukasawa, K; Iwama, T; Ikeura, C; Ikuta, M; Suzuki-Takahashi, I; Iwasawa, Y; Hayama, T; Nishimura, S; Morishima, H Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design. J Med Chem 44:4615-27 (2001) [PubMed] Article
Target
Name:
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C]
Synonyms:
CDK4/Cyclin D | Cyclin-Dependent Kinase 4 (CDK4)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
CDK4/D complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components.
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Human
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
Component 2
Name:
G1/S-specific cyclin-D1 [L188C]
Synonyms:
BCL1 | CCND1 | CCND1_HUMAN | Cyclin D | PRAD1
Type:
Enzyme Subunit
Mol. Mass.:
33634.57
Organism:
Human
Description:
P24385[L188C]
Residue:
295
Sequence:
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDGSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVASCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
Inhibitor
Name:
BDBM6639
Synonyms:
5-(2H-1,3-benzodioxol-5-ylmethylidene)-1,3-diazinane-2,4,6-trione | Cyclic urea deriv. 6
Type:
Small organic molecule
Emp. Form.:
C12H8N2O5
Mol. Mass.:
260.2023
SMILES:
O=[#6]-1-[#7]-[#6](=O)\[#6](=[#6]\c2ccc3-[#8]-[#6]-[#8]-c3c2)-[#6](=O)-[#7]-1
Substrate
Name:
G1 peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1483.28
Organism:
n/a
Description:
n/a
Residue:
13
Sequence:
RPPTLSPIPHIPR