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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM259920
Substrate
n/a
Meas. Tech.
Fluorometric Assays
pH
8±n/a
Temperature
303.15±n/a K
Ki
15.542±n/a nM
Comments
extracted
Citation
 Heiser, U; Buchholz, M; Sommer, R; Meyer, A; Demuth, H Inhibitors US Patent  US9512115 Publication Date 12/6/2016 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM259920
Synonyms:
US9512115, 24
Type:
Small organic molecule
Emp. Form.:
C21H17F2N5O2
Mol. Mass.:
409.3888
SMILES:
FC1(F)CCN(C1)c1ccc(cc1C#N)[C@H]1COC(=O)N1c1ccc2[nH]cnc2c1 |r|
Structure:
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