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Target
Transthyretin
Ligand
BDBM408979
Substrate
n/a
Meas. Tech.
In vitro evaluation of inhibitory activity against WT-TTR
IC50
1590±270 nM
Citation
 Vieira Simões, CJ; Lourenço de Almeida, ZC; Vasconcelos Dias de Pinho e Melo, TM; Pontes Meireles Ferreira de Brito, RM; Silva Costa, DC; Cabral Cardoso Lopes, AL Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) US Patent  US10377729 Publication Date 8/13/2019 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM408979
Synonyms:
US10377729, Compound 2OH-PCB80
Type:
Small organic molecule
Emp. Form.:
C12H4Cl4O2
Mol. Mass.:
321.972
SMILES:
[O-]c1c(Cl)cc(cc1Cl)-c1cc(Cl)c([O-])c(Cl)c1
Structure:
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