Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM45881
Substrate
n/a
Meas. Tech.
Enzyme Kinetic Assay
IC50
<100±n/a nM
Citation
Pinkerton, AB; Dahl, R; Cosford, ND; Millan, JL Sulfonamide compounds and uses as TNAP inhibitors US Patent US10370333 Publication Date 8/6/2019
More Info.:
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
Inhibitor
Name:
BDBM45881
Synonyms:
5-bromanyl-2-methoxy-N-pyridin-3-yl-benzenesulfonamide | 5-bromo-2-methoxy-N-(3-pyridinyl)benzenesulfonamide | 5-bromo-2-methoxy-N-(3-pyridyl)benzenesulfonamide | 5-bromo-2-methoxy-N-pyridin-3-ylbenzenesulfonamide | MLS-0090851.0001 | US10370333, Example I-3 | cid_839345
Type:
Small organic molecule
Emp. Form.:
C12H11BrN2O3S
Mol. Mass.:
343.196
SMILES:
COc1ccc(Br)cc1S(=O)(=O)Nc1cccnc1