Reaction Details Report a problem with these data
Target
TGF-beta receptor type-1 [4-503,T204D]
Ligand
BDBM412770
Substrate
n/a
Meas. Tech.
Biological Assays
IC50
1.40±n/a nM
Citation
Harikrishnan, LS; Fink, BE; Borzilleri, RM; Tonukunuru, G; Sankara Warrier, J TGF beta receptor antagonists US Patent US10399987 Publication Date 9/3/2019
More Info.:
Target
Name:
TGF-beta receptor type-1 [4-503,T204D]
Synonyms:
ALK5 | SKR4 | TGF-beta receptor type-1 T204D | TGFBR1 | TGFR-1 T204D | TGFR1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55650.84
Organism:
Human
Description:
P36897 T204D
Residue:
500
Sequence:
AVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
Inhibitor
Name:
BDBM412770
Synonyms:
1-(((2-(6-(difluoromethyl)pyridin-2-yl)-4-((3-fluoropyridin-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)amino)-2-methylpropan-2-ol | US10399987, Example 35
Type:
Small organic molecule
Emp. Form.:
C22H22F3N7O
Mol. Mass.:
457.4516
SMILES:
CC(C)(O)CNCc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(n1)C(F)F