Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM419276
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
91.0±n/a nM
Citation
 Gobbi, L; Grether, U; Guba, W; Kretz, J; Martin, RE; Westphal, MV; Ijzerman, AP [1,2,3]triazolo[4,5-D]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor US Patent  US10457685 Publication Date 10/29/2019 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM419276
Synonyms:
(3S)-1-(5-tert-Butyl-3-{[2-(isothiocyanatomethyl)phenyl]methyl}-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol | US10457685, Example 5
Type:
Small organic molecule
Emp. Form.:
C21H25N7OS
Mol. Mass.:
423.535
SMILES:
CC(C)(C)c1nc(N2CC[C@H](O)C2)c2nnn(Cc3ccccc3CN=C=S)c2n1 |r|
Structure:
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