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Target
Histone-lysine N-methyltransferase EZH2
Ligand
BDBM435570
Substrate
n/a
Meas. Tech.
Biological Assay (10X SAM)
Ki
1.000±n/a nM
Citation
 Collins, MR; Kania, RS; Kumpf, RA; Kung, P; Richter, DT; Sutton, SC; Wythes, MJ Substituted dihydroisoquinolinone compounds US Patent  US10570121 Publication Date 2/25/2020 
Target
Name:
Histone-lysine N-methyltransferase EZH2
Synonyms:
ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6
Type:
Protein
Mol. Mass.:
85367.84
Organism:
Homo sapiens (Human)
Description:
Q15910
Residue:
746
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
  
Inhibitor
Name:
BDBM435570
Synonyms:
US10570121, Example 80
Type:
Small organic molecule
Emp. Form.:
C24H27Cl2N3O2
Mol. Mass.:
460.396
SMILES:
CC(=C1CCNCC1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl |(-4.67,3.08,;-4.67,1.54,;-6,.77,;-7.34,1.54,;-8.67,.77,;-8.67,-.77,;-7.34,-1.54,;-6,-.77,;-3.33,.77,;-3.33,-.77,;-2,-1.54,;-2,-3.08,;-.67,-.77,;.67,-1.54,;2,-.77,;2,.77,;3.33,1.54,;4.67,.77,;4.67,-.77,;3.33,-1.54,;6,-1.54,;7.34,-.77,;8.67,-1.54,;7.34,.77,;6,1.54,;6,3.08,;.67,1.54,;.67,3.08,;-.67,.77,;-2,1.54,;-2,3.08,)|
Structure:
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