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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM455825
Substrate
n/a
Meas. Tech.
Kinase Binding Assay
Ki
<100±n/a nM
Citation
 Vechorkin, O; Atasoylu, O; Ye, HF; Liu, K; Zhang, K; Yao, W Cyanoindazole compounds and uses thereof US Patent  US10722495 Publication Date 7/28/2020 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM455825
Synonyms:
US10722495, Example 33
Type:
Small organic molecule
Emp. Form.:
C25H24FN5O
Mol. Mass.:
429.4894
SMILES:
CNCc1cc(C)c(c(F)c1)-c1cc2c(n[nH]c2cc1C#N)-c1ccc(nc1)C(C)(C)O |(-.29,5.07,;-1.62,5.84,;-2.96,5.07,;-2.96,3.53,;-1.62,2.76,;-1.62,1.22,;-.29,.45,;-2.96,.45,;-4.29,1.22,;-5.62,.45,;-4.29,2.76,;-2.96,-1.09,;-1.62,-1.86,;-1.62,-3.4,;-.48,-4.43,;-1.11,-5.84,;-2.64,-5.68,;-2.96,-4.17,;-4.29,-3.4,;-4.29,-1.86,;-5.62,-1.09,;-6.96,-.32,;1.01,-4.03,;1.41,-2.55,;2.89,-2.15,;3.98,-3.24,;3.58,-4.72,;2.1,-5.12,;5.47,-2.84,;6.56,-3.93,;6.96,-2.44,;5.87,-1.35,)|
Structure:
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