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Target
Cyclic GMP-AMP synthase [155-522]
Ligand
BDBM457585
Substrate
n/a
Meas. Tech.
Biochemical Activity Assay
IC50
<20±n/a nM
Citation
 Ndubaku, CO; Katibah, GE; Roberts, TC; Sung, L; Ciblat, S; Raeppel, F; Ly, VL; Ramtohul, YK; Rybak, T; Zaky, M; Gillard, L; Ismaili, H Pyrazolopyrimidinone compounds and uses thereof US Patent  US10738056 Publication Date 8/11/2020 
Target
Name:
Cyclic GMP-AMP synthase [155-522]
Synonyms:
C6orf150 | CGAS | CGAS_HUMAN | Cyclic GMP-AMP synthase (CGAS) (155-522) | MB21D1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43018.25
Organism:
Human
Description:
Q8N884[155-522]
Residue:
368
Sequence:
RRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
  
Inhibitor
Name:
BDBM457585
Synonyms:
US10738056, Compound D1030
Type:
Small organic molecule
Emp. Form.:
C21H21N5O3
Mol. Mass.:
391.4231
SMILES:
Cc1nn2c([nH]c(C)c(-c3nnc(o3)C3CCCOC3)c2=O)c1-c1ccccc1
Structure:
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