Reaction Details Report a problem with these data
Target
Fatty acid 2-hydroxylase
Ligand
BDBM483682
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
<100±n/a nM
Citation
 Grice, CA; Wiener, JJ; Weber, OD; Duncan, KK Pyrazole MAGL inhibitors US Patent  US10927105 Publication Date 2/23/2021 
Target
Name:
Fatty acid 2-hydroxylase
Synonyms:
FA2H | FA2H_HUMAN | FAAH | FAXDC1 | Fatty acid alpha-hydroxylase | Fatty acid hydroxylase domain-containing protein 1
Type:
Protein
Mol. Mass.:
42806.38
Organism:
Human
Description:
Q7L5A8
Residue:
372
Sequence:
MAPAPPPAASFSPSEVQRRLAAGACWVRRGARLYDLSSFVRHHPGGEQLLRARAGQDISADLDGPPHRHSANARRWLEQYYVGELRGEQQGSMENEPVALEETQKTDPAMEPRFKVVDWDKDLVDWRKPLLWQVGHLGEKYDEWVHQPVTRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVLYLSWSYYRTFAQGNVRLFTSFTTEYTVAVPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVIGVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHTLTPEKPHLKTQ
  
Inhibitor
Name:
BDBM483682
Synonyms:
1-(trans-5-([1,1'- biphenyl]-3- yloxy)- octahydrocyclopenta- [c]pyrrole-2- carbonyl)-1H- pyrazole-3- carboxylic acid | US10927105, Ex 125 | US11655217, Example 125
Type:
Small organic molecule
Emp. Form.:
C24H23N3O4
Mol. Mass.:
417.4571
SMILES:
OC(=O)c1ccn(n1)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)Oc1cccc(c1)-c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: