Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM499510
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
5.70±n/a nM
Citation
Chen, Y; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Ramsden, PD Cycloalkyl substituted triazole compounds as agonists of the APJ receptor US Patent US11020395 Publication Date 6/1/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM499510
Synonyms:
US11020395, Example 92.0
Type:
Small organic molecule
Emp. Form.:
C21H28N8O5S
Mol. Mass.:
504.563
SMILES:
COc1cnc(nc1)[C@@H](C)[C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1-c1c(OC)ncnc1OC |r,wU:10.11,8.9,(9.11,.32,;7.77,1.09,;6.44,.32,;6.44,-1.22,;5.11,-1.99,;3.77,-1.22,;3.77,.32,;5.11,1.09,;2.44,-1.99,;2.44,-3.53,;1.1,-1.22,;1.1,.32,;-.23,-1.99,;-1,-3.33,;.54,-3.33,;-1.56,-1.22,;-2.9,-1.99,;-3.37,-3.46,;-4.91,-3.46,;-5.39,-1.99,;-6.93,-1.99,;-8.02,-.9,;-9.11,-1.99,;-8.02,-3.08,;-4.14,-1.09,;-4.14,.45,;-5.48,1.22,;-6.81,.45,;-8.14,1.22,;-5.48,2.76,;-4.14,3.53,;-2.81,2.76,;-2.81,1.22,;-1.48,.45,;-.14,1.22,)|