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Target
Casein kinase I isoform epsilon
Ligand
BDBM302447
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
55±n/a nM
Citation
 Velaparthi, U; Darne, CP; Liu, P; Wittman, MD; Pearce, BC; Araujo, EM; Dasgupta, B; Nair, JS; Janakiraman, SK; Rachamreddy, CR; Mettu, MR; Karuppiah, AM; Reddy, BS; Nagalakshmi, P; Bora, RO; Maheshwarappa, SH; Kumaravel, S; Mullick, D; Sistla, R Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors US Patent  US9598423 Publication Date 3/21/2017 
Target
Name:
Casein kinase I isoform epsilon
Synonyms:
Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:
Protein
Mol. Mass.:
47340.25
Organism:
Homo sapiens (Human)
Description:
P49674
Residue:
416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
  
Inhibitor
Name:
BDBM302447
Synonyms:
2-(3-Fluorophenyl)-N5- (1,1,1-trifluoro-2- methylpropan-2-yl)-6,7- dihydropyrazolo[1,5-a] pyrazine-3,5(4H)- dicarboxamide | US9598423, Example 13
Type:
Small organic molecule
Emp. Form.:
C18H20F3N5O2
Mol. Mass.:
395.3789
SMILES:
CC(C)(NC(=O)N1CCn2nc(c(C(N)=O)c2C1)-c1cccc(F)c1)C(F)F
Structure:
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