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Target
Serine hydroxymethyltransferase, mitochondrial [30-504]
Ligand
BDBM512928
Substrate
n/a
Meas. Tech.
SHMT1 and SHMT2 Activity Assays
IC50
<1000±n/a nM
Citation
Mainolfi, N SHMT inhibitors and uses thereof US Patent US11091451 Publication Date 8/17/2021
More Info.:
Target
Name:
Serine hydroxymethyltransferase, mitochondrial [30-504]
Synonyms:
GLYM_HUMAN | SHMT2 | Serine hydroxymethyltransferase, mitochondrial (30-504)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52566.80
Organism:
Human
Description:
aa 30-504
Residue:
475
Sequence:
NAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDEH