Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM303072
Substrate
n/a
Meas. Tech.
In Vitro ORL-1 Receptor Binding Assay
EC50
15.0±1.7 nM
Citation
 Tadesse, D; Tafesse, L; Zhou, X Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof US Patent  US9598447 Publication Date 3/21/2017 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM303072
Synonyms:
US9598447, Ref No. VV
Type:
Small organic molecule
Emp. Form.:
C27H38N3O4P
Mol. Mass.:
499.5821
SMILES:
CC1(C)[C@@H]2CC1[C@H](CCN1[C@H]3CCC[C@@H]1C[C@@H](C3)n1c3ccccc3nc(c1=O)P(O)(O)=O)CC2 |r,THB:8:9:16.17.15:11.13.12|
Structure:
Search PDB for entries with ligand similarity: