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Target
Tyrosine-protein kinase ITK/TSK
Ligand
BDBM515341
Substrate
n/a
Meas. Tech.
IMAP (Immobilized Metal Ion Affinity-Based Fluorescence Polarization) Assay
IC50
>1000±n/a nM
Citation
 Barf, T; de Zwart, E; Verkaik, S; Hoogenboom, N; Demont, D Imidazopyrazine inhibitors of Bruton's tyrosine kinase US Patent  US11110088 Publication Date 9/7/2021 
Target
Name:
Tyrosine-protein kinase ITK/TSK
Synonyms:
EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk
Type:
Protein
Mol. Mass.:
71839.20
Organism:
Homo sapiens (Human)
Description:
Q08881
Residue:
620
Sequence:
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
  
Inhibitor
Name:
BDBM515341
Synonyms:
US11110088, Compound Table 1.15
Type:
Small organic molecule
Emp. Form.:
C26H22F3N7O3
Mol. Mass.:
537.4932
SMILES:
COc1cc(ccc1C(=O)Nc1cc(ccn1)C(F)(F)F)-c1nc([C@H](C)NC(=O)C#CC)n2ccnc(N)c12 |r|
Structure:
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