Reaction Details Report a problem with these data
Target
Zinc finger protein Helios
Ligand
BDBM526276
Substrate
n/a
Meas. Tech.
Prolabel Quantification of IKZF1, IKZF2, or GSPT1 Protein Levels in 293GT Cells
EC50
23100±n/a nM
Citation
 Beckwith, RE; Bonazzi, S; Cernijenko, A; Ma, F; Ware, NF 3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof US Patent  US11185537 Publication Date 11/30/2021 
Target
Name:
Zinc finger protein Helios
Synonyms:
HELIOS | IKZF2 | IKZF2_HUMAN | Ikaros family zinc finger protein 2 | ZNFN1A2
Type:
Protein
Mol. Mass.:
59578.38
Organism:
Human
Description:
Q9UKS7
Residue:
526
Sequence:
METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYSQVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDTTKAPKGSLKDIYKVFNGEGEQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRSQDRYEFSSHIVRGEHTFH
  
Inhibitor
Name:
BDBM526276
Synonyms:
2-(2,6-dioxopiperidin-3-yl)-5- (methyl((1S,2S)-2- ((pyridin-3- ylmethyl)amino)cyclohexyl)amino) isoindoline-1,3-dione | US11185537, Compound I-143
Type:
Small organic molecule
Emp. Form.:
C26H29N5O4
Mol. Mass.:
475.5396
SMILES:
CN([C@H]1CCCC[C@@H]1NCc1cccnc1)c1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: