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Target
Monocarboxylate transporter 1
Ligand
BDBM345263
Substrate
n/a
Meas. Tech.
Biological Activity Assay 4
IC50
39000±n/a nM
Citation
 Parnell, KM; McCall, J; Romero, D Heterocyclic inhibitors of MCT4 US Patent  US11292767 Publication Date 4/5/2022 
Target
Name:
Monocarboxylate transporter 1
Synonyms:
MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1
Type:
PROTEIN
Mol. Mass.:
53956.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1451367
Residue:
500
Sequence:
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKAAESPDQKDTDGGPKEEESPV
  
Inhibitor
Name:
BDBM345263
Synonyms:
2-[[5-(2-Chlorophenyl)-1-[(2- chlorophenyl)methyl]pyrazol-3- yl]methoxy]-2-methyl-propanoic acid 1H NMR (CD3OD, 400 MHz) $#948; 1.53 (s, 6H), 4.58 (s, 2H), 5.28 (s, 2H), 6.43 (s, 1H), 6.78-7.81 (m, 1H), 7.16-34 (m, 5H), 7.38- 7.42 (m, 1H), 7.50-7.56 (m, 1H). | US10202350, Example 9 | US10214492, Example 9 | US11292767, Example 9 | US11724989, Example 9
Type:
Small organic molecule
Emp. Form.:
C21H20Cl2N2O3
Mol. Mass.:
419.301
SMILES:
CC(C)(OCc1cc(-c2ccccc2Cl)n(Cc2ccccc2Cl)n1)C(O)=O
Structure:
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