Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK1 [837-1142]
Ligand
BDBM246861
Substrate
n/a
Meas. Tech.
In Vitro JAK Kinase Assay
IC50
<10±n/a nM
Citation
 Howell, MD; Smith, P Treatment of hidradenitis suppurativa using JAK inhibitors US Patent  US11304949 Publication Date 4/19/2022 
Target
Name:
Tyrosine-protein kinase JAK1 [837-1142]
Synonyms:
JAK1 | JAK1 (aa 837-1142) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (837-1142) | Tyrosine-protein kinase JAK1 (aa 837-1142)
Type:
n/a
Mol. Mass.:
35230.04
Organism:
Homo sapiens (Human)
Description:
P23458[837-1142]
Residue:
306
Sequence:
FFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF
  
Inhibitor
Name:
BDBM246861
Synonyms:
3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]propanenitrile | US10005788, 2 (2nd peak, cis-) | US10053465, 3 | US10065963, Compound 3 | US10125150, Example 3 | US10336759, # 3 | US10479803, Example 3 | US10519163, Example 3 | US10675284, Example 3 | US11084822, Example 3 | US11130767, # 3 | US11136326, Example 3 | US11304949, Compound 6 | US11324749, Comp. No. 6 | US11406640, Comp. No. 6 | US11596632, Comp. No. 6 | US20240058343, Compound 6 | US9732097, Example 3
Type:
Small organic molecule
Emp. Form.:
C21H19ClN8
Mol. Mass.:
418.882
SMILES:
Clc1cccc(n1)N1CCC(C1)C(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
Structure:
Search PDB for entries with ligand similarity: