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Target
Anoctamin-1
Ligand
BDBM509682
Substrate
n/a
Meas. Tech.
Automated Whole-Cell Patch Clamp Assay
EC50
750±n/a nM
Citation
 Collingwood, S; Mccarthy, C; Hargrave, JD; Hay, DA; Schofield, TB; Ellam, S; Buxton, CS; Habgood, M; Ingram, PN; Ma, CY; Napier, SC; Shaikh, AK; Smith, MR; Stimson, CC; Walker, ER Compounds US Patent  US11364246 Publication Date 6/21/2022 
Target
Name:
Anoctamin-1
Synonyms:
ANO1 | ANO1_HUMAN | DOG1 | Discovered on gastrointestinal stromal tumors protein 1 | ORAOV2 | Oral cancer overexpressed protein 2 | TAOS2 | TMEM16A | Transmembrane protein 16A | Tumor-amplified and overexpressed sequence 2
Type:
PROTEIN
Mol. Mass.:
114103.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_828184
Residue:
986
Sequence:
MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPCNHHNTKACPDSLGSPAPSHAYHGGVL
  
Inhibitor
Name:
BDBM509682
Synonyms:
US11364246, Example 30.4 | US20200361871A1, Example 30.4
Type:
Small organic molecule
Emp. Form.:
C20H20ClN3O2
Mol. Mass.:
369.845
SMILES:
CC12CC(C1)(C2)NC(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccn1
Structure:
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