Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [H232R]
Ligand
BDBM573859
Substrate
n/a
EC50
3.70±n/a nM
Citation
 Altman, MD; Andresen, B; Chang, W; Cumming, JN; Otte, RD; Trotter, BW Cyclic di-nucleotide compounds as sting agonists US Patent  US11453697 Publication Date 9/27/2022 
Target
Name:
Envelope glycoprotein
Synonyms:
GP | GP1,2 | VGP_EBOZ5
Type:
Protein
Mol. Mass.:
74450.60
Organism:
ZEBOV
Description:
P87666
Residue:
676
Sequence:
MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTAVSNRAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSPQPPTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDTPPATTAAGPLKAENTNTSKGTDLLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRARREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
  
Inhibitor
Name:
BDBM573859
Synonyms:
2-amino-9- [(5R,7R,8S,12aR,14R,15R,15aR,16R)-14-(6- amino-9H-purin-9-yl)-15,16-difluoro-2,10- dihydroxy-2,10-dioxidooctahydro-12H-5,8- methanofuro[3,2-l][1,3,6,9,11,2,10] pentaoxadiphosphacyclotetradecin-7-yl]-1,9- dihydro-6H-purin-6-one | US11453697, Example 23 | US11453697, Example 26
Type:
Small organic molecule
Emp. Form.:
C20H22F2N10O11P2
Mol. Mass.:
678.3934
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(O)(=O)OC3[C@@H](COP(O)(=O)O[C@H]1C2F)O[C@H]([C@H]3F)n1cnc2c(N)ncnc12 |r|
Structure:
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