Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [H232R]
Ligand
BDBM573923
Substrate
n/a
EC50
1.90±n/a nM
Citation
 Altman, MD; Andresen, B; Chang, W; Cumming, JN; Otte, RD; Trotter, BW Cyclic di-nucleotide compounds as sting agonists US Patent  US11453697 Publication Date 9/27/2022 
Target
Name:
Envelope glycoprotein
Synonyms:
GP | GP1,2 | VGP_EBOZ5
Type:
Protein
Mol. Mass.:
74450.60
Organism:
ZEBOV
Description:
P87666
Residue:
676
Sequence:
MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTAVSNRAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSPQPPTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDTPPATTAAGPLKAENTNTSKGTDLLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRARREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
  
Inhibitor
Name:
BDBM573923
Synonyms:
2-amino-9- [(5R,7R,8R,12aR,14R,15R,15aS,18R)-14-(6- amino-9H-purin-9-yl)-2,10,18-trihydroxy-2,10- disulfidohexahydro-14H-15,12a- (epoxymethano)-5,8-methanofuro [3,2-l][1,3,6,9,11,2,10] pentaoxadiphosphacyclotetradecin-7(12H)-yl]- 1,9-dihydro-6H-purin-6-one (Diastereomer 1) | US11453697, Example 93 | US11453697, Example 94 | US11453697, Example 95
Type:
Small organic molecule
Emp. Form.:
C21H24N10O11P2S2
Mol. Mass.:
718.553
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(S)(=O)OC3[C@@H]4OC[C@]3(COP(S)(=O)O[C@H]1C2O)O[C@H]4n1cnc2c(N)ncnc12 |r|
Structure:
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