Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [H232R]
Ligand
BDBM574021
Substrate
n/a
EC50
3.30±n/a nM
Citation
 Altman, MD; Andresen, B; Chang, W; Cumming, JN; Otte, RD; Trotter, BW Cyclic di-nucleotide compounds as sting agonists US Patent  US11453697 Publication Date 9/27/2022 
Target
Name:
Envelope glycoprotein
Synonyms:
GP | GP1,2 | VGP_EBOZ5
Type:
Protein
Mol. Mass.:
74450.60
Organism:
ZEBOV
Description:
P87666
Residue:
676
Sequence:
MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTAVSNRAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSPQPPTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDTPPATTAAGPLKAENTNTSKGTDLLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRARREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
  
Inhibitor
Name:
BDBM574021
Synonyms:
5-amino-3-[(5R,7R,8R,12aR,14R,15aS,16S)-14- (4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-16- hydroxy-2,10-dioxido-2,10-disulfanyloctahydro- 12H-5,8-methanofuro[3,2-l][1,3,9,11,6,2,10] tetraoxathiadiphosphacyclotetradecin-7-yl]-3,6- dihydro-7H-[1,2,3]triazolo[4,5-d] pyrimidin-7-one (Diastereomer 1) | US11453697, Example 111 | US11453697, Example 112 | US11453697, Example 113 | US11453697, Example 114
Type:
Small organic molecule
Emp. Form.:
C19H23N11O9P2S3
Mol. Mass.:
707.597
SMILES:
Nc1nc2n(nnc2c(=O)[nH]1)[C@@H]1S[C@@H]2COP(S)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(S)(=O)O[C@@H]1[C@@H]2O)c1cnc2c(N)ncnn12 |r|
Structure:
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