Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [H232R]
Ligand
BDBM574079
Substrate
n/a
EC50
1.40±n/a nM
Citation
 Altman, MD; Andresen, B; Chang, W; Cumming, JN; Otte, RD; Trotter, BW Cyclic di-nucleotide compounds as sting agonists US Patent  US11453697 Publication Date 9/27/2022 
Target
Name:
Envelope glycoprotein
Synonyms:
GP | GP1,2 | VGP_EBOZ5
Type:
Protein
Mol. Mass.:
74450.60
Organism:
ZEBOV
Description:
P87666
Residue:
676
Sequence:
MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTAVSNRAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSPQPPTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDTPPATTAAGPLKAENTNTSKGTDLLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRARREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
  
Inhibitor
Name:
BDBM574079
Synonyms:
5-amino-3-[(5R,7R,8S,112aR,14R,15aS,16S)- 14-(6-amino-9H-purin-9-yl)-12a-ethynyl-16- fluoro-2,10-dioxido-2,10-disulfanyloctahydro- 12H-5,8-methanofuro[3,2- l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetra- decin-7-yl]-3,6-dihydro-7H-[1,2,3]triazolo[4,5- d]pyrimidin-7-one (Diastereomer 1) | US11453697, Example 207 | US11453697, Example 208 | US11453697, Example 209
Type:
Small organic molecule
Emp. Form.:
C21H22FN11O9P2S2
Mol. Mass.:
717.544
SMILES:
Nc1nc2n(nnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(S)(=O)O[C@H]3C[C@@H](O[C@@]3(COP(S)(=O)O[C@@H]1[C@H]2F)C#C)n1cnc2c(N)ncnc12 |r|
Structure:
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