Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [H232R]
Ligand
BDBM574158
Substrate
n/a
EC50
3.70±n/a nM
Citation
 Altman, MD; Andresen, B; Chang, W; Cumming, JN; Otte, RD; Trotter, BW Cyclic di-nucleotide compounds as sting agonists US Patent  US11453697 Publication Date 9/27/2022 
Target
Name:
Envelope glycoprotein
Synonyms:
GP | GP1,2 | VGP_EBOZ5
Type:
Protein
Mol. Mass.:
74450.60
Organism:
ZEBOV
Description:
P87666
Residue:
676
Sequence:
MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTAVSNRAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSPQPPTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDTPPATTAAGPLKAENTNTSKGTDLLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRARREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
  
Inhibitor
Name:
BDBM574158
Synonyms:
2-amino-9-[(2R,5R,7R,8R,10R, 12aR,14R,15S,15aR,16S)-15-fluoro-16- hydroxy-2,10-dioxido-14-(6-oxo-1,6- dihydro-9H-purin-9-yl)-2,10- disulfanyloctahydro-12H-5,8- methanofuro[3,2-l][1,3,9,11,6,2,10] tetraoxathiadiphosphacyclotetradecin-7- yl]-1,9-dihydro-6H-purin-6-one (Diastereomer 1) | US11453697, Example 323
Type:
Small organic molecule
Emp. Form.:
C20H22FN9O10P2S3
Mol. Mass.:
725.584
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1S[C@@H]2CO[P@](S)(=O)O[C@@H]3[C@@H](CO[P@](S)(=O)O[C@@H]1[C@@H]2O)O[C@H]([C@H]3F)n1cnc2c1nc[nH]c2=O |r|
Structure:
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