Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50507695
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
525±n/a nM
Citation
 Chern, J; Yu, C; Liu, J; Ho, Y; Wu, C; Huang, C; Hung, P Histone deacetylases (HDACs) inhibitors US Patent  US11535598 Publication Date 12/27/2022 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50507695
Synonyms:
CHEMBL4554270 | US11535598, Compound 15
Type:
Small organic molecule
Emp. Form.:
C25H23N3O5
Mol. Mass.:
445.4672
SMILES:
COc1ccccc1CCn1c(=O)n(Cc2ccc(cc2)C(=O)NO)c2ccccc2c1=O
Structure:
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