Reaction Details Report a problem with these data
Target
Pantothenate kinase 3
Ligand
BDBM649480
Substrate
n/a
Meas. Tech.
hPanK3 IC50
IC50
3.80±0.4 nM
Citation
 Lee, RE; Tangallapally, RP; Rock, CO; Jackowski, S; Edwards, AV; Yun, MK; Subramanian, C; Zamboni, R; Reddy, TJ Small molecule modulators of pantothenate kinases US Patent  US11891378 Publication Date 2/6/2024 
Target
Name:
Pantothenate kinase 3
Synonyms:
PANK3 | PANK3_HUMAN | Pantothenate kinase 3 | Pantothenic acid kinase 3 | hPanK3
Type:
PROTEIN
Mol. Mass.:
41093.59
Organism:
Human
Description:
ChEMBL_109587
Residue:
370
Sequence:
MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTLQTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS
  
Inhibitor
Name:
BDBM649480
Synonyms:
US11891378, Example 10
Type:
Small organic molecule
Emp. Form.:
C20H23ClN4O
Mol. Mass.:
370.876
SMILES:
C[C@@H]1CN(CCN1C(=O)Cc1ccc(cc1)C1CC1)c1ccc(Cl)nn1 |r|
Structure:
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