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Target
Aurora kinase A
Ligand
BDBM25617
Substrate
Substrate Peptide SerThr 01
Meas. Tech.
In Vitro BRAF Kinase Assay
IC50
3400±n/a nM
Citation
 Tsai, J; Lee, JT; Wang, W; Zhang, J; Cho, H; Mamo, S; Bremer, R; Gillette, S; Kong, J; Haass, NK; Sproesser, K; Li, L; Smalley, KS; Fong, D; Zhu, YL; Marimuthu, A; Nguyen, H; Lam, B; Liu, J; Cheung, I; Rice, J; Suzuki, Y; Luu, C; Settachatgul, C; Shellooe, R; Cantwell, J; Kim, SH; Schlessinger, J; Zhang, KY; West, BL; Powell, B; Habets, G; Zhang, C; Ibrahim, PN; Hirth, P; Artis, DR; Herlyn, M; Bollag, G Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A 105:3041-6 (2008) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM25617
Synonyms:
N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide | PLX4720
Type:
Small organic molecule
Emp. Form.:
C17H14ClF2N3O3S
Mol. Mass.:
413.826
SMILES:
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Substrate Peptide SerThr 01
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
358.43
Organism:
n/a
Description:
Z -LYTE biochemical assay kit (SelectScreen; Invitrogen).
Residue:
3
Sequence:
NA