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Target
RNA-directed RNA polymerase
Ligand
BDBM384089
Substrate
n/a
Meas. Tech.
Measurement of Interferon Production in Human PBMC
EC50
590±n/a nM
Citation
 Bonfanti, J; Doublet, FM; Embrechts, W; Fortin, JM; McGowan, DC; Muller, P; Raboisson, PJ Purine derivatives for the treatment of viral infections US Patent  US10280167 Publication Date 5/7/2019 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM384089
Synonyms:
US10280167, Example 12
Type:
Small organic molecule
Emp. Form.:
C16H15N7O
Mol. Mass.:
321.3366
SMILES:
Cn1ccnc1-c1nc(N)c2[nH]c(=O)n(Cc3ccccc3)c2n1
Structure:
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