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Target
Mitogen-activated protein kinase 1
Ligand
BDBM30185
Substrate
EGFR Peptide Substrate
Meas. Tech.
Kinase Selectivity Assay
pH
7.5±n/a
Temperature
296.15±n/a K
IC50
3440±n/a nM
Citation
 Anderson, DR; Meyers, MJ; Vernier, WF; Mahoney, MW; Kurumbail, RG; Caspers, N; Poda, GI; Schindler, JF; Reitz, DB; Mourey, RJ Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem 50:2647-54 (2007) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM30185
Synonyms:
CHEMBL226403 | Pyrrolopyridine, 16
Type:
Small organic molecule
Emp. Form.:
C21H16N4O
Mol. Mass.:
340.3779
SMILES:
O=C1NCCc2[nH]c(cc12)-c1ccnc(c1)-c1cnc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
EGFR Peptide Substrate
Synonyms:
EGFRP
Type:
Peptide
Mol. Mass.:
2447.81
Organism:
n/a
Description:
n/a
Residue:
22
Sequence:
KKRELVEPLTPSGEAPNQALLR