Reaction Details Report a problem with these data
Target
Procathepsin L [114-333,T223A]
Ligand
BDBM31973
Substrate
BDBM22047
Meas. Tech.
Cathepsin Inhibition Assay
pH
7±n/a
Temperature
310.15±n/a K
IC50
316±n/a nM
Citation
Asaad, N; Bethel, PA; Coulson, MD; Dawson, JE; Ford, SJ; Gerhardt, S; Grist, M; Hamlin, GA; James, MJ; Jones, EV; Karoutchi, GI; Kenny, PW; Morley, AD; Oldham, K; Rankine, N; Ryan, D; Wells, SL; Wood, L; Augustin, M; Krapp, S; Simader, H; Steinbacher, S Dipeptidyl nitrile inhibitors of Cathepsin L. Bioorg Med Chem Lett 19:4280-3 (2009) [PubMed] Article
More Info.:
Target
Name:
Procathepsin L [114-333,T223A]
Synonyms:
CATL1_HUMAN | CTSL | CTSL1 | Cathepsin L
Type:
Cysteine Protease
Mol. Mass.:
24128.88
Organism:
Human
Description:
P07711[114-333,T223A]
Residue:
220
Sequence:
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDAGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Inhibitor
Name:
BDBM31973
Synonyms:
Dipeptidyl nitrile inhibitor, 6
Type:
Small organic molecule
Emp. Form.:
C19H24ClN3O2
Mol. Mass.:
361.866
SMILES:
Clc1cccc(C[C@H](NC(=O)C2CCCCCC2)C(=O)NCC#N)c1 |r|
Substrate
Name:
BDBM22047
Synonyms:
CBZ-Phe-Arg 7-amido-4-methylcoumarin | Z-Phe-Arg-AMC
Type:
Fluorogenic substrate
Emp. Form.:
C33H36N6O6
Mol. Mass.:
612.6755
SMILES:
[#6]-c1cc(=O)oc2cc(-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c3ccccc3)-[#7]-[#6](=O)-[#8]-[#6]-c3ccccc3)ccc12