Reaction Details Report a problem with these data
Target
Neutrophil collagenase
Ligand
BDBM400682
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>10000±n/a nM
Citation
 Kamei, N; Sumikawa, Y; Kamimura, D; Todo, S; Yamada, T; Tokuoka, S Pyridone derivative, pharmaceutical containing the same and methods of use thereof US Patent  US10000476 Publication Date 6/19/2018 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM400682
Synonyms:
US10000476, Compound I-41
Type:
Small organic molecule
Emp. Form.:
C23H20FN3O3
Mol. Mass.:
405.4216
SMILES:
Cc1cccn(CC2(NC(=O)NC2=O)c2ccc(Cc3ccc(F)cc3)cc2)c1=O
Structure:
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