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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50137
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors
IC50
4148.059491±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay (2008)[AID] 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50137
Synonyms:
MLS000560945 | N-[[(E)-3-(2-furyl)-1-methyl-prop-2-enylidene]amino]-2-(2-thienyl)acetamide | N-[[(E)-4-(2-furanyl)but-3-en-2-ylidene]amino]-2-thiophen-2-ylacetamide | N-[[(E)-4-(furan-2-yl)but-3-en-2-ylidene]amino]-2-thiophen-2-yl-ethanamide | N-[[(E)-4-(furan-2-yl)but-3-en-2-ylidene]amino]-2-thiophen-2-ylacetamide | SMR000175287 | Thiophen-2-yl-acetic acid (3-furan-2-yl-1-methyl-allylidene)-hydrazide | cid_739483
Type:
Small organic molecule
Emp. Form.:
C14H14N2O2S
Mol. Mass.:
274.338
SMILES:
CC(C=Cc1ccco1)=NNC(=O)Cc1cccs1 |w:9.10,2.1|
Structure:
Search PDB for entries with ligand similarity: