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Target
SUMO-activating enzyme subunit 1
Ligand
BDBM55013
Substrate
n/a
Meas. Tech.
uHTS HTRF assay for identification of inhibitors of SUMOylation
IC50
15630±n/a nM
Citation
 PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-activating enzyme subunit 1
Synonyms:
AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38440.84
Organism:
Homo sapiens (Human)
Description:
gi_17390638
Residue:
346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
  
Inhibitor
Name:
BDBM55013
Synonyms:
2-[(5Z)-5-(3-chloro-4-hydroxy-5-methoxy-benzylidene)-2,4-diketo-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide | 2-[(5Z)-5-[(3-chloranyl-5-methoxy-4-oxidanyl-phenyl)methylidene]-2,4-bis(oxidanylidene)-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)ethanamide | 2-[(5Z)-5-[(3-chloro-4-hydroxy-5-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide | 2-[(5Z)-5-[(3-chloro-4-hydroxy-5-methoxyphenyl)methylidene]-2,4-dioxo-3-thiazolidinyl]-N-(2-fluorophenyl)acetamide | 2-[5-(3-chloro-4-hydroxy-5-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide | MLS000974649 | SMR000497148 | cid_1322017
Type:
Small organic molecule
Emp. Form.:
C19H14ClFN2O5S
Mol. Mass.:
436.841
SMILES:
COc1cc(\C=C2/SC(=O)N(CC(=O)Nc3ccccc3F)C2=O)cc(Cl)c1O
Structure:
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