Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM61056
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
>10000±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM61056
Synonyms:
3-Amino-6-trifluoromethoxy-thieno[2,3-b]quinoline-2-carboxylic acid [4-(pyrrolidine-1-sulfonyl)-phenyl]-amide | 3-amino-N-(4-pyrrolidin-1-ylsulfonylphenyl)-6-(trifluoromethoxy)thieno[2,3-b]quinoline-2-carboxamide | 3-amino-N-(4-pyrrolidinosulfonylphenyl)-6-(trifluoromethoxy)thieno[2,3-b]quinoline-2-carboxamide | 3-amino-N-[4-(1-pyrrolidinylsulfonyl)phenyl]-6-(trifluoromethoxy)-2-thieno[2,3-b]quinolinecarboxamide | 3-azanyl-N-(4-pyrrolidin-1-ylsulfonylphenyl)-6-(trifluoromethyloxy)thieno[2,3-b]quinoline-2-carboxamide | MLS000553472 | SMR000171173 | cid_3231291
Type:
Small organic molecule
Emp. Form.:
C23H19F3N4O4S2
Mol. Mass.:
536.547
SMILES:
Nc1c(sc2nc3ccc(OC(F)(F)F)cc3cc12)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC1
Structure:
Search PDB for entries with ligand similarity: